Compounded
Tirzepatide

Tirzepatide is a novel medication that acts as a dual GIP and GLP-1 receptor agonist, enhancing the body's natural ability to regulate blood sugar and promote weight loss.

Tirzepatide is suitable for adults with obesity or overweight with at least one weight-related condition, such as hypertension, type 2 diabetes, or dyslipidemia, upon a doctor's recommendation.

Side effects may include gastrointestinal disturbances, such as nausea, decreased appetite, diarrhea, and potential hypoglycemia, especially when combined with other diabetes medications.

Tirzepatide is administered via injection once a week, with the dosage gradually increasing to minimize gastrointestinal side effects and improve tolerability.

Tirzepatide is a dual GIP (Glucose-dependent insulinotropic polypeptide) and GLP-1 (Glucagon-like peptide-1) receptor agonist. Mounjaro® and Zepbound® are two brand names for the same medication, Tirzepatide. 

Mounjaro® is FDA-approved for the treatment of type 2 diabetes and is being studied for its effectiveness in weight loss. Zepbound® is specifically FDA approved for weight loss in adults with a BMI of 30 or higher. It is also approved for those who are overweight and have an additional health condition, such as high blood pressure.

Semaglutide Scripts offers compounded Tirzepatide, formulated by Licensed U.S. compound pharmacies using the active ingredient Tirzepatide but is not FDA-approved.

Tirzepatide helps with weight loss by mimicking the effects of natural gut hormones. It slows down gastric emptying, reduces appetite, and improves insulin sensitivity, all of which contribute to decreased calorie intake and weight reduction.
 

Many patients begin to experience weight loss within the first few weeks, but significant results are usually achieved after several months of consistent treatment. The timeline may vary depending on individual factors such as lifestyle and starting weight.
 

Tirzepatide has been shown to promote significant weight loss, often greater than other weight loss medications like semaglutide. It can also improve metabolic health by lowering blood sugar levels and reducing the risk of diabetes-related complications.

Tirzepatide is a dual agonist that activates both the GLP-1 (Glucagon-Like Peptide-1) and GIP (Glucose-Dependent Insulinotropic Polypeptide) receptors. This dual activation enhances the body's natural ability to regulate blood sugar and promote weight loss.

• GLP-1 receptor activation increases insulin secretion, suppresses glucagon release, delays gastric emptying, and reduces appetite, all contributing to blood sugar control and weight loss.
• GIP receptor activation also enhances insulin release, especially when blood glucose levels are elevated. Additionally, GIP may improve fat metabolism and promote lipolysis (fat breakdown), leading to more significant weight loss compared to GLP-1 receptor agonists alone.

The combination of these two mechanisms makes Tirzepatide more potent for both glucose regulation and weight loss compared to other medications that act on GLP-1 alone, such as Semaglutide

No. Ozempic® and Wegovy® are approved by the FDA and contain semaglutide, a GLP-1 receptor agonist, while Tirzepatide targets both GIP and GLP-1 receptors. Although both medications (Ozempic® or Wegovy®) are used for weight loss, they act on different hormonal pathways. Compounded Tirzepatide does target both GIP and GLP-1 receptors however it is not FDA approved.
 

Here's a breakdown of their regulatory status, quality control, and pricing:

1. Regulatory Status

FDA-Approved Tirzepatide (Mounjaro® and Zepbound®): These are medications that have gone through rigorous clinical trials and received FDA approval for safety, efficacy, and consistency in treating specific conditions like type 2 diabetes (Mounjaro®) or obesity (Zepbound®). They are manufactured under strict guidelines by Eli Lilly, the pharmaceutical company that holds the patent for Tirzepatide.
Compounded Tirzepatide: This version is made by compounding pharmacies, which are not subject to the same FDA approval process as brand-name medications Mounjaro® or Zepbound®. Compounding is typically done when a drug is tailored for an individual patient's needs, such as adjusting the dosage or combining it with other ingredients..

        2. Quality and Consistency

FDA-Approved Tirzepatide: Mounjaro® and Zepbound® are produced under highly controlled conditions with consistent dosing, purity, and efficacy. Each batch is manufactured to meet FDA standards, ensuring patients receive a predictable and reliable product.
Compounded Tirzepatide: While compounding pharmacies follow state-level regulations and safety protocols, they may not always meet the same stringent quality and consistency standards as FDA-approved medications. Potency, purity, and even the absorption rate could vary depending on the compounding pharmacy’s practices.

        3. Pricing

FDA-Approved Tirzepatide: Brand-name medications like Mounjaro® and Zepbound® may not be covered by insurance providers and the cost out of pocket may vary extensively.
Compounded Tirzepatide: Compounded versions are often cheaper; however, the lower price reflects the fact that these medications have not gone through the same extensive testing and regulatory approval process as their branded counterparts Mounjaro® and Zepbound®. Your decision to choose between which to take shouldn't be based around price but rather which is more suitable as determined by your medical provider. 

        4. Availability

FDA-Approved Tirzepatide: Mounjaro® is widely available and prescribed for type 2 diabetes, with Zepbound® expected to follow for obesity treatment. However, supply chain issues and insurance coverage can impact availability.
Compounded Tirzepatide: Availability is usually through specialized compounding pharmacies, and patients may find it easier to obtain since it is sometimes prescribed off-label for weight loss or other purposes.

In short, FDA-approved Mounjaro® and Zepbound® are subject to stringent quality controls and regulatory oversight, whereas compounded Tirzepatide offers a less regulated alternative. Patients opting for compounded versions should be aware of the variability in quality and consistency. Please note it is critical to discuss these key differences with your medical provider so you are aware of the risks that may accompany compounded Tirzepatide versus FDA-approved Mounjaro® and Zepbound® .
 

You may be a good candidate if you are overweight or obese with a body mass index over 30 and have struggled with weight loss through traditional means like diet and exercise. A healthcare provider will evaluate your medical history to determine eligibility.

Yes, Tirzepatide is approved for people with type 2 diabetes under the brand name Mounjaro®. Compounded Tirzepatide can be prescribed off-label for weight loss, including for people with diabetes.

 Yes, clinical trials have shown that Tirzepatide can be effective for weight loss in people without diabetes, though it is not yet FDA-approved for this purpose. The compounded Tirzepatide we offer may be an option for weight loss management after a thorough evaluation by your medical provider .

Yes, clinical trials have shown that Tirzepatide can be effective for weight loss in people without diabetes, though it is not yet FDA-approved for this purpose. The compounded Tirzepatide we offer may be an option for weight loss management after a thorough evaluation by your medical provider .

Typically, compounded Tirzepatide is prescribed for adults over 18 years old with a BMI of 30 or greater, or with a BMI of 27 or greater if there are obesity-related health conditions.

Tirzepatide may be safe for those with high blood pressure or heart conditions, but a healthcare provider will need to assess your health status and current medications to ensure there are no contraindications.

Common side effects include nausea, vomiting, diarrhea, constipation, and decreased appetite. These are often mild and tend to diminish over time.

Yes, nausea is a common side effect, especially when starting treatment or adjusting the dose. It usually improves as your body adjusts to the medication. Semaglutide Scripts compounded Tirzepatide is custom formulated with Pyridoxine (Vitamin B6) to aid in preventing nausea and water retention.

In rare cases, Tirzepatide can cause serious side effects such as pancreatitis or gallbladder problems. It's important to disclose any pre-existing medical conditions to your healthcare provider prior to you starting the treatment.

Long-term risks are still being studied, but potential concerns may include the risk of pancreatitis and thyroid tumors. Ongoing medical supervision is recommended and critical to avoid adverse side effects.

If you experience side effects, contact your healthcare provider immediately and discuss your symptoms. Mild side effects should improve over time. Regular communication with your medical provider about your experience usually improves outcomes.

The medication is administered as a subcutaneous injection.

Tirzepatide is taken once a week, and the dosage may be adjusted based on your response and tolerance to the treatment.

Yes, the dosage may be increased gradually over time to minimize side effects and optimize results.

If you miss a dose, take it as soon as you remember, unless it's too close to your next scheduled dose. In that case, skip the missed dose and continue as normal. Follow the directions provided with the medication from the pharmacy as directed by your healthcare practitioner.

Yes, most patients find the self-injection process easy with proper instructions. Your healthcare provider will guide you on how to administer the medication.

The cost of compounded Tirzepatide varies depending on the compounding pharmacy. Semaglutide scripts offer all inclusive treatment packages that are month to month, or save more with a 3 month treatment plan and even more with the 6 month treatment plan.

Most insurance plans do not cover compounded Tirzepatide for weight loss, as it is not yet FDA-approved for this purpose.

Some medical providers, including Semaglutide Scripts, offer discounts or payment plans for compounded Tirzepatide. 
Choose from these 3 payment plans with Semaglutide Scripts:

• Month to month no long term contract
• Pay for 3 month treatment plan upfront (save at least 10%)
• Pay for 6 month treatment plan upfront (save at least 20%/best value)